RESUMO
Pronounced antitumor effect of Thymalin in doses lower than the therapeutic doses was shown in experiments on albino outbred male rats with transplanted sarcoma 45. Tumor growth arrest and its regression were observed in more than half of animals and in other cases, the growth was suppressed by 78%. Microstructural changes in the thymus were analyzed. Significant increase in lymphoproliferative activity and the content of tissue basophils and plasmocytes in the thymus lobules was observed. Tumor regression was accompanied by the development of stable antistress adaptation reactions of calm and elevated activation. High efficiency of Thymalin can be attributed to the use of lower doses of the substance and their modulation during the treatment course in accordance with the regimes of activation therapy.
Assuntos
Timo/efeitos dos fármacos , Timo/patologia , Hormônios do Timo/uso terapêutico , Adjuvantes Imunológicos , Animais , Masculino , Ratos , Sarcoma/tratamento farmacológico , Sarcoma/patologiaRESUMO
This paper briefly reviews the ways of activation of the antitumor resistance mechanisms developed on the basis of the concept of the periodic system of general nonspecific adaptational reactions of the body. The principles of the formation of effective influences by electromagnetic radiation using biologically active substances are described. A comparison of the criteria and conceptions of the theory of adaptational reactions to some concepts and categories of synergetics is made. The features of dynamics of the studied parameters upon effective influences are considered. Antistress nature of the systemic effects of ferromagnetic nanoparticles on tumor bearing animals is shown. The, possible mechanisms of regression of large tumor under the influence of two different factors--modulated electromagnetic radiation and magnetite nanoparticles--are discussed. The cases of a change of the order parameter in connection with the development of antistress areactivity and regression of experimental tumors under the influence of the combined electromagnetic impact are analyzed.
Assuntos
Campos Eletromagnéticos , Nanopartículas de Magnetita/uso terapêutico , Neoplasias/fisiopatologia , Adaptação Fisiológica/efeitos da radiação , Animais , Transformação Celular Neoplásica/efeitos da radiação , Humanos , Neoplasias/radioterapia , RatosRESUMO
This paper presents a brief overview of the results of the original researches of biological responses induced by agents of cytostatic and regulatory actions in small doses, as well as weak electromagnetic radiation of different frequency bands. The possibility of obtaining the expressed antitumor, antistress and geroprotective effects has been shown. The question of the relation of system mechanisms of realization of these effects with structural rearrangements in biological fluids, as well as the promising directions for optimizing the therapeutic properties of the informational impacts are discussed.
Assuntos
Citostáticos/farmacologia , Radiação Eletromagnética , Modelos Biológicos , Neoplasias Experimentais/terapia , Animais , Relação Dose-Resposta a Droga , Feminino , Masculino , Camundongos , Neoplasias Experimentais/patologiaRESUMO
Changes in transplanted sarcoma 45 tissue in outbred albino rats with tumor regression under the effect of magnetite nanoparticles (magnetic fluid) were studied by light and electron microscopy. The ultrastructure and cell death types in regressing tumors and signs of cell-cell interactions with participation of macrophages, lymphocytes, neutrophils, and degranulating mast cells were described. Some possible mechanisms of a pronounced antitumor activity of magnetite nanoparticles were discussed.
Assuntos
Antineoplásicos/uso terapêutico , Comunicação Celular , Nanopartículas de Magnetita/uso terapêutico , Sarcoma Experimental/patologia , Animais , Animais não Endogâmicos , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Ensaios de Seleção de Medicamentos Antitumorais , Leucócitos/imunologia , Masculino , Transplante de Neoplasias , Fagocitose , Ratos , Sarcoma Experimental/tratamento farmacológico , Sarcoma Experimental/imunologia , Carga TumoralRESUMO
The effects of copper nanoparticles on the structure and function of the immune system organs (thymus and spleen) and intensity of free radical processes in the spleens of rats with sarcoma 45 were studied. A relationship between morphological and biochemical changes and antitumor efficiency of copper nanoparticles was demonstrated.
Assuntos
Antineoplásicos/administração & dosagem , Cobre/química , Nanopartículas Metálicas/administração & dosagem , Sarcoma/tratamento farmacológico , Baço/efeitos dos fármacos , Neoplasias Esplênicas/tratamento farmacológico , Timo/efeitos dos fármacos , Animais , Antineoplásicos/síntese química , Catalase/metabolismo , Radicais Livres/metabolismo , Glutationa Peroxidase/metabolismo , Histocitoquímica , Injeções Intralesionais , Injeções Intraperitoneais , Masculino , Malondialdeído , Nanopartículas Metálicas/química , Tamanho da Partícula , Ratos , Sarcoma/patologia , Baço/patologia , Neoplasias Esplênicas/patologia , Superóxido Dismutase/metabolismo , Timo/patologia , Carga Tumoral/efeitos dos fármacosRESUMO
Effects of low-intensity microwave radiation with bioactive frequency were studied in rats with transplanted sarcoma 45. After exposure to microwave radiation in the regimen of activation therapy, the antitumor effect was observed in 50% animals (marked inhibition of tumor growth or its partial regression). Light and electron microscopy revealed destructive changes in the tumor tissue, accumulation of activation of immune system cells, and signs of the increase in tumor cell differentiation.